Open Access<p>Tryptophol Coating Reduces Catheter-Related Cerebral and Pulmonary Infections by <em>Scedosporium apiospermum</em></p>
Author(s) -
Thitinan Kitisin,
Watcharamat Muangkaew,
Sumate Ampawong,
Passanesh Sukphopetch
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s255489
Subject(s) - scedosporium apiospermum , medicine , catheter , voriconazole , microbiology and biotechnology , pathology , surgery , biology , antifungal
Central venous catheter (CVC) is a medical device that is used to administer medication for a long duration. Colonization by an emerging opportunistic pathogen Scedosporium apiospermum in the CVC lumen is frequently reported to cause severe complications in patients. Here, we describe the effect of fungal quorum-sensing molecule (QSM) known as tryptophol (TOH) to control S. apiospermum colonization in catheter tube lumens in both in vitro and in vivo models.