Open Access<p>Association of CRISPR/Cas System with the Drug Resistance in <em>Klebsiella pneumoniae</em></p>
Author(s) -
Gang Wang,
Guobin Song,
Yuanhong Xu
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s253380
Subject(s) - klebsiella pneumoniae , crispr , biology , plasmid , drug resistance , microbiology and biotechnology , multiple drug resistance , antibiotic resistance , carbapenem , gene , antibiotics , genetics , escherichia coli
Klebsiella pneumoniae is a common opportunistic pathogen and its production of extended-spectrum β-lactamases (ESBL) and carbapenemases leads to drug resistance. Clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated genes (Cas) are widespread in the genome of many bacteria and are a defense mechanism against foreign invaders such as plasmids and viruses.