Open Access<p>Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients</p>
Author(s) -
Fatemeh Saheb SharifAskari,
Narjes Saheb Sharif-Askari,
Adnane Guella,
Ali Alabdullah,
Hour Bashar Al Sheleh,
Afnan Maher Hoory AlRawi,
Enad Sami Haddad,
Qutayba Hamid,
Rabih Halwani,
Rifat Hamoudi
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s251966
Subject(s) - medicine , klebsiella pneumoniae , gastroenterology , urinary system , type 2 diabetes mellitus , neutrophil to lymphocyte ratio , type 2 diabetes , hazard ratio , diabetes mellitus , immunology , lymphocyte , escherichia coli , biology , endocrinology , confidence interval , biochemistry , gene
Extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the most common uropathogens causing UTI (urinary tract infection) in type 2 diabetes mellitus (T2DM). Circulatory inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are usually dysregulated during UTI. However, the differential regulation of these inflammatory signatures during E. coli and K. pneumoniae UTI in T2DM has not been determined.