Open Access<p>Molecular Investigations of Linezolid Resistance in Enterococci <em>OptrA</em> Variants from a Hospital in Shanghai</p>
Author(s) -
Pei Li,
Yang Yang,
Li Ding,
Xiaogang Xu,
Ding Lin
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s251490
Subject(s) - linezolid , 23s ribosomal rna , biology , agar dilution , enterococcus faecalis , microbiology and biotechnology , enterococcus , multilocus sequence typing , enterococcus faecium , genetics , minimum inhibitory concentration , genotype , antibiotics , gene , bacteria , vancomycin , escherichia coli , staphylococcus aureus , ribosome , rna
The OptrA protein is a member of ATP-binding cassette (ABC) transporters, a transporter family which can confer resistance to oxazolidinone antibiotics by transferring plasmid. We aim to describe the distribution of optrA -harbored Enterococcus in Huashan hospital in 2017 and to address the effects of optrA mutations on the susceptibility of linezolid antibiotic drug.