Open Access<p>Plasmid Profiling and Occurrence of β-Lactamase Enzymes in Multidrug-Resistant Uropathogenic <em>Escherichia coli</em> in Kathmandu, Nepal</p>
Author(s) -
Upendra Thapa Shrestha,
Sabnum Shrestha,
Nabaraj Adhikari,
Komal Raj Rijal,
Basudha Shrestha,
Bipin Adhikari,
Megha Raj Banjara,
Prakash Ghimire
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s250591
Subject(s) - microbiology and biotechnology , escherichia coli , biology , plasmid , imipenem , klebsiella pneumoniae , multiple drug resistance , antibiotic resistance , antibiotics , dna , biochemistry , genetics , gene
Extended-spectrum β-lactamases (ESBL) among Gram-negative bacteria, predominantly Escherichia coli ( E. coli ), in Nepal, have been rising. The main objectives of this study were to determine the prevalence of uropathogenic E. coli , antibiotic resistance, ESBLs, ABLs (AmpC type β-lactamases), MBLs (metallo-β-lactamases) and KPCs ( Klebsiella pneumoniae carbapenemases) and their correlation with plasmid profiling patterns among patients with urinary tract infections in a tertiary hospital in Kathmandu, Nepal.