Open Access<p>Serotypes and Antimicrobial Susceptibility of Nasopharyngeal Isolates of <em>Streptococcus pneumoniae</em> from Children Less Than 5 Years Old in Egypt</p>
Author(s) -
Amani El-Kholy,
M.M. Badawy,
Maha A. Gad,
May Sherif Soliman
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s250315
Subject(s) - streptococcus pneumoniae , serotype , medicine , pneumococcal conjugate vaccine , pneumonia , microbiology and biotechnology , pneumococcal infections , conjugate vaccine , antimicrobial , antibiotics , virology , biology
Streptococcus pneumoniae (S. pneumoniae) is the etiology of severe and life-threatening infections in children less than 5 years old. Though pneumococcal conjugate vaccines (PCVs) are effective in the prevention of pneumococcal infections, yet they are not included in the National Immunization Program in Egypt pending the identification of pathogenic serotypes. As S. pneumoniae colonization of the pharynx predisposes to pneumonia and invasive pneumococcal disease (IPD) caused by the colonizing serotypes, identification of the nasopharyngeal (NP) serotypes can be a surrogate to the invasive serotypes. In this study, we aimed to 1. Identify the serotypes and antimicrobial susceptibility testing (AST) of Streptococcus pneumoniae colonizing the nasopharynx of Egyptian children younger than 5 years in two successive winter seasons. 2. Correlate the identified serotypes with vaccine coverage of the 13-valent conjugate pneumococcal vaccines (PCV13). 3. Compare the serotypes and AST of S. pneumoniae from NP to those of IPD that were routinely identified in our clinical laboratory during the study period.