Open Access<p>Antimicrobial Peptide AMP-17 Affects <em>Candida albicans</em> by Disrupting Its Cell Wall and Cell Membrane Integrity</p>
Author(s) -
Hui Ma,
Xinyu Zhao,
Longbing Yang,
Peipei Su,
Ping Fu,
Jian Peng,
Na Yang,
Guo Guo
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s250278
Subject(s) - candida albicans , cell wall , corpus albicans , cell , cell membrane , biology , flow cytometry , microbiology and biotechnology , cell growth , membrane , antimicrobial , chemistry , biochemistry
Candida albicans is associated with high mortality among immunocompromised patients. Resistance to and toxic side effects of antifungal drugs require the development of alternative antifungal agents. AMP-17 is a novel antimicrobial peptide derived from Musca domestica that exerts excellent antifungal effects against the Candida species. In this article, we discuss the potential mechanism of AMP-17 against C. albicans from the perspective of affecting the latter's cell external structure.