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The emergence of the plasmid-borne colistin-resistant gene ( mcr-1 ) poses a great threat to human health. What is worse, the recent observations of the co-existence of mcr-1 with other antimicrobial resistance genes in some bacteria cause further concern. Here, we present the first report of a wild Escherichia coli strain that co-carries an mcr-1 encoding phage-like IncY plasmid (pR15_MCR-1) and a bla  NDM-5 encoding IncX3 plasmid (pR15_NDM-5) from a pharmaceutical industry, wastewater treatment plant, in China. This study highlights the spreading of E. coli carrying both mcr-1 and bla  NDM-5 genes in the pharmaceutical industry.

infection and drug resistance

&lt;p&gt;Co-Existence of &lt;em&gt;mcr-1&lt;/em&gt; and &lt;em&gt;bla&lt;/em&gt;&lt;sub&gt;NDM-5&lt;/sub&gt; in an &lt;em&gt;Escherichia&lt;/em&gt; &lt;em&gt;coli&lt;/em&gt; Strain Isolated from the Pharmaceutical Industry, WWTP&lt;/p&gt;