Open Access<p>Co-Existence of <em>mcr-1</em> and <em>bla</em><sub>NDM-5</sub> in an <em>Escherichia</em> <em>coli</em> Strain Isolated from the Pharmaceutical Industry, WWTP</p>
Author(s) -
Ho Jae Han,
Wenhong Liu,
Xinjie Cui,
Xu Cheng,
Xin Jiang
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s245047
Subject(s) - plasmid , escherichia coli , gene , biology , mcr 1 , colistin , microbiology and biotechnology , bacteria , strain (injury) , antimicrobial , enterobacteriaceae , genetics , anatomy
The emergence of the plasmid-borne colistin-resistant gene ( mcr-1 ) poses a great threat to human health. What is worse, the recent observations of the co-existence of mcr-1 with other antimicrobial resistance genes in some bacteria cause further concern. Here, we present the first report of a wild Escherichia coli strain that co-carries an mcr-1 encoding phage-like IncY plasmid (pR15_MCR-1) and a bla NDM-5 encoding IncX3 plasmid (pR15_NDM-5) from a pharmaceutical industry, wastewater treatment plant, in China. This study highlights the spreading of E. coli carrying both mcr-1 and bla NDM-5 genes in the pharmaceutical industry.