Open Access<p>Protective Efficacy of the OprF/OprI/PcrV Recombinant Chimeric Protein Against <em>Pseudomonas aeruginosa</em> in the Burned BALB/c Mouse Model</p>
Author(s) -
Mohammad Hadi Fakoor,
Seyed Latif Mousavi Gargari,
Parviz Owlia,
A Sabokbar
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s244081
Subject(s) - recombinant dna , immunogenicity , pseudomonas aeruginosa , titer , antibody , spleen , escherichia coli , microbiology and biotechnology , fusion protein , pseudomonas exotoxin , biology , virology , immunology , bacteria , gene , biochemistry , genetics
Pseudomonas aeruginosa infection is the major cause of death in burn patients. Thus, in this study, a chimeric vaccine harboring the OprF 185-350 -OprI 22-83 -PcrV was designed and expressed in Escherichia coli . The immunogenicity of the recombinant chimer, OprI, OprF, and PcrV was studied in a burned mouse model.