Open Access<p>Dendritic Cells Promote Treg Expansion but Not Th17 Generation in Response to <em>Talaromyces marneffei</em> Yeast Cells</p>
Author(s) -
Yanping Tang,
Hui Zhang,
Hanzi Xu,
Wen Zeng,
Ye Qiu,
Chang Tan,
Shudan Tang,
Jianquan Zhang
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s239906
Subject(s) - cd80 , flow cytometry , cd86 , foxp3 , microbiology and biotechnology , dendritic cell , proinflammatory cytokine , biology , immunology , context (archaeology) , chemistry , cd40 , t cell , immune system , in vitro , cytotoxic t cell , inflammation , paleontology , biochemistry
Dendritic cells (DCs) with both proinflammatory and tolerogenic properties have been implicated in modulation of CD4 + T cell responses in many fungal diseases. However, the role of DC in the context of Talaromyces marneffei ( T. marneffei ) infection has not been determined. In this study, we aimed to study the effect of the yeast form of T. marneffei yeasts on DCs, as well as the role of DCs in modulating T helper 17 (Th17) and regulatory T (Treg) cell responses to the pathogen.