Open Access<p>Efflux Pumps Contribute to Intrinsic Clarithromycin Resistance in Clinical, <em>Mycobacterium abscessus</em> Isolates</p>
Author(s) -
Qi Guo,
Jianhui Chen,
Shaoyan Zhang,
Yuzhen Zou,
Yongjie Zhang,
Dongdong Huang,
Zhemin Zhang,
Bing Li,
Haiqing Chu
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s239850
Subject(s) - clarithromycin , mycobacterium abscessus , efflux , microbiology and biotechnology , biology , gene , virulence , mycobacterium , mutation , genotype , antibiotics , genetics , bacteria
The emergence of clarithromycin resistance is a challenge in treating Mycobacterium abscessus infections. Known mechanisms that contribute to intrinsic clarithromycin resistance focus on rrl gene-related mutations, but resistant clinical isolates often exhibit an inconsistent rrl genotype.