Open Access<p>Trends in Molecular Markers Associated with Resistance to Sulfadoxine-Pyrimethamine (SP) Among <em>Plasmodium falciparum</em> Isolates on Bioko Island, Equatorial Guinea: 2011–2017</p>
Author(s) -
Liyun Lin,
Jian Li,
Huiying Huang,
Xueyan Liang,
Tingting Jiang,
Jiangtao Chen,
Carlos Salas Ehapo,
Urbano Monsuy Eyi,
Yuzhong Zheng,
GuangCai Zha,
DongDe Xie,
Yuling Wang,
Weizhong Chen,
Xiangzhi Liu,
Yaqun Liu
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s236898
Subject(s) - dihydropteroate synthase , sulfadoxine/pyrimethamine , plasmodium falciparum , malaria , biology , pyrimethamine , sulfadoxine , piperaquine , drug resistance , haplotype , genetics , allele , gene , artemisinin , immunology
Antimalarial drug resistance is one of the major challenges in global efforts to control and eliminate malaria. In 2006, sulfadoxine-pyrimethamine (SP) replaced with artemisinin-based combination therapy (ACT) on Bioko Island, Equatorial Guinea, in response to increasing SP resistance, which is associated with mutations in the dihydrofolate reductase ( Pfdhfr ) and dihydropteroate synthase ( Pfdhps ) genes.