Open Access<p><em>Acinetobacter baumannii</em> Efflux Pumps and Antibiotic Resistance</p>
Author(s) -
Seyyed Naser Abdi,
Reza Ghotaslou,
Khudaverdi Ganbarov,
Ahmad Mobed,
Asghar Tanomand,
Mehdi Yousefi,
Mohammad Asgharzadeh,
Hossein Samadi Kafil
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s228089
Subject(s) - efflux , acinetobacter baumannii , microbiology and biotechnology , antibiotics , antibiotic resistance , multiple drug resistance , drug resistance , biofilm , biology , pseudomonas aeruginosa , bacteria , genetics
Acinetobacter baumannii is a nosocomial pathogen and gram-negative coccobacillus that is responsible for opportunistic infections, pneumonia, and infections of the urinary tract, bloodstream, skin, and soft tissue. This bacterium poses a major public health problem due to inducing resistance to several drugs, isolates, multidrug treatment, and occasionally pan drugs. Drug resistance is not only a major concern caused by A. baumannii but also is considered as the main challenge in many other pathogens. Several factors such as the efflux pump are associated with antibiotic resistance, biofilm production, and genetic mutations. In this review, A. baumannii is introduced in then some of the practical works conducted on the existing efflux pump are reviewed. The importance of the efflux pump is considered in this paper in relation to the antibiotic resistance and mechanisms developed for the inhibition of these pumps as well.