Open Access<p>Evaluation of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for identifying VIM- and SPM-type metallo-β-lactamase-producing <em>Pseudomonas aeruginosa</em> clinical isolates</p>
Author(s) -
Jin Li,
Weiwei Hu,
Min Li,
Shaoli Deng,
Qing Huang
Publication year - 2019
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s211984
Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , typing , mass spectrometry , matrix assisted laser desorption/ionization , genotype , chemistry , biology , chromatography , bacteria , gene , desorption , genetics , organic chemistry , adsorption
Metallo-β-lactamase-producing Pseudomonas aeruginosa (MBL-PA) are important causative agents of nosocomial infections and are associated with significant mortality rates, especially in intensive care units. The timely detection and typing of these strains is essential for surveillance, outbreak prevention and antibiotic therapy optimization. In this study, fifteen VIM-type and fifteen SPM-type MBL-PA strains were selected as strains to establish MALDI-TOF MS SuperSpectra.