Open Access<p>Characterization of a novel <em>bla</em><sub>NDM-5</sub>-harboring IncFII plasmid and an <em>mcr-1</em>-bearing IncI2 plasmid in a single <em>Escherichia coli</em> ST167 clinical isolate</p>
Author(s) -
Lijuan Xu,
Ping Wang,
Jing Cheng,
Shangshang Qin,
Wei-Hong Xie
Publication year - 2019
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s192998
Subject(s) - chemistry
The spread of the plasmid-mediated, colistin-resistance gene mcr-1 into New Delhi metallo-β-lactamase (NDM)-producing bacterial isolates can cause untreatable infections. In this study, we conducted a molecular characterization of a novel, conjugative, bla NDM-5 -positive IncFII plasmid (pNDM-EC16-50) together with an mcr-1 -bearing IncI2 plasmid in a single Escherichia coli ST167 clinical isolate EC16-50.