Open Access<p>Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet</p>
Author(s) -
Dragana Komnenov,
Peter Levanovich,
Natalia Perecki,
Charles S. Chung,
Noreen F. Rossi
Publication year - 2020
Publication title -
integrated blood pressure control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 20
ISSN - 1178-7104
DOI - 10.2147/ibpc.s257205
Subject(s) - medicine , endocrinology , fructose , pulse wave velocity , population , arterial stiffness , blood pressure , chemistry , food science , environmental health
High fructose and salt consumption continues to be prevalent in western society. Existing studies show that a rat model reflecting a diet of fructose and salt consumed by the upper 20th percentile of the human population results in salt-sensitive hypertension mitigated by treatment with an antioxidant. We hypothesized that dietary fructose, rather than glucose, combined with high salt leads to aortic stiffening and decreased renal artery compliance. We also expect that daily supplementation with the antioxidant, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (+T; Tempol), will ameliorate the increase in mean arterial pressure (MAP) and vascular changes.