Open AccessSymptomatic Cryptococcal Meningitis with Negative Serum and Cerebrospinal Fluid Cryptococcal Antigen Tests
Author(s) -
Vivien Nanfuka,
Mkhoi L. Mkhoi,
Jane Gakuru,
Richard Kwizera,
Joseph Baruch Baluku,
Felix Bongomin,
David B. Meya
Publication year - 2021
Publication title -
hiv/aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 22
ISSN - 1179-1373
DOI - 10.2147/hiv.s328084
Subject(s) - cerebrospinal fluid , cryptococcosis , cryptococcus , flucytosine , amphotericin b , fluconazole , medicine , meningitis , cryptococcus neoformans , context (archaeology) , immunology , antifungal , surgery , biology , dermatology , microbiology and biotechnology , paleontology
Cryptococcal meningitis is a leading cause of mortality in advanced HIV disease. A positive cerebrospinal fluid cryptococcal antigen (CrAg) test defines cryptococcal meningitis. Herein, we present a patient with serum and cerebrospinal fluid CrAg negative cryptococcal meningitis, despite a positive cerebrospinal fluid India ink examination and quantitative culture.