Open AccessThe Anti-Obesity Potential of Cyperus rotundus Extract Containing Piceatannol, Scirpusin A and Scirpusin B Rhizomes: Preclinical and Clinical Evaluations
Author(s) -
Muhammed Majeed,
Kalyanam Nagabhushanam,
B. K. Bhat,
Mohammad Javed Ansari,
Anjali Pandey,
Sarang Bani,
Lakshmi Mundkur
Publication year - 2022
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s348412
Subject(s) - medicine , overweight , endocrinology , obesity , adverse effect , tolerability , adipose tissue , weight loss , lipid profile , diabetes mellitus , pharmacology
Obesity is a complex medical problem that increases the risk of other diseases like diabetes, cardiovascular diseases, and fatty liver disease. The present study evaluated the efficacy and safety of Cyperus rotundus rhizome extract (CRE), standardized to contain Piceatannol, Scirpusin A, and Scirpusin B (5% total Stilbenoids) in overweight individuals. The mechanism of activity was evaluated in a diet-induced mice model of obesity and adipocytes in vitro.