Open AccessDecreased Levels of miR-126 and miR-132 in Plasma and Vitreous Humor of Non-Proliferative Diabetic Retinopathy Among Subjects with Type-2 Diabetes Mellitus
Author(s) -
Subhodip Pramanik,
Chinmay Saha,
Subhankar Chowdhury,
Chiranjit Bose,
Nitai P. Bhattacharyya,
Lakshmi Kanta Mondal
Publication year - 2022
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s346097
Subject(s) - diabetic retinopathy , medicine , type 2 diabetes mellitus , diabetes mellitus , oxidative stress , endocrinology , vascular endothelial growth factor , retinopathy , microangiopathy , endothelial dysfunction , type 2 diabetes , vegf receptors
Diabetic retinopathy (DR), the leading cause of blindness among working adults, is an urgent public health problem as diabetes mellitus (DM) is increasing at an alarming rate. Hyperglycemia-induced endothelial dysfunction is the principal contributing factor leading to the development of microangiopathy. Altered levels of microRNA (miR), the negative regulator of protein-coding genes, have been observed and considered to be markers for DR. Present study aimed to find out whether miR levels in plasma could be effective biomarkers to differentiate between type 2 diabetes mellitus (T2DM) with non-proliferative retinopathy (NPDR) from T2DM with no-DR (DNR).