Open AccessRPS4Y1 Promotes High Glucose-Induced Endothelial Cell Apoptosis and Inflammation by Activation of the p38 MAPK Signaling
Author(s) -
Yuan Chen,
Yiheng Chen,
Chonghui Tang,
Qian Zhao,
Tailin Xu,
Qi Kang,
Bin Jiang,
Li Zhang
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s329209
Subject(s) - p38 mitogen activated protein kinases , inflammation , microbiology and biotechnology , apoptosis , mapk/erk pathway , signal transduction , chemistry , endothelial stem cell , cancer research , biology , medicine , biochemistry , in vitro
Endothelial dysfunction is a key pathological basis for diabetes mellitus complications, including diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. This study aimed to reveal the functional role of ribosomal protein S4 Y-linked 1 (RPS4Y1) in endothelial dysfunction.