Open AccessHigh-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes
Author(s) -
David R. Powell,
JeanPierre Revelli,
Deon Doree,
Christopher M. DaCosta,
Urvi Desai,
Melanie K. Shadoan,
Lawrence A. Rodriguez,
Michael A. Mullens,
Qi Yang,
ZhiMing Ding,
Laura L. Kirkpatrick,
Peter Vogel,
Brian Zambrowicz,
Arthur Sands,
Kenneth A. Platt,
Gwenn M. Hansen,
Robert Brommage
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s322083
Subject(s) - phenotype , obesity , gene knockout , biology , gene , genetics , medicine , endocrinology
Obesity is a major public health problem. Understanding which genes contribute to obesity may better predict individual risk and allow development of new therapies. Because obesity of a mouse gene knockout (KO) line predicts an association of the orthologous human gene with obesity, we reviewed data from the Lexicon Genome5000 TM high throughput phenotypic screen (HTS) of mouse gene KOs to identify KO lines with high body fat.