Open AccessPossible Regulation of bFGF Expression by Mast Cells in Osteoarthritis Patients with Obesity: A Cross-Sectional Study
Author(s) -
Ken Takata,
Kentaro Uchida,
Shotaro Takano,
Manabu Mukai,
Gen Inoue,
Hiroyuki Sekiguchi,
Jun Aikawa,
Masayuki Miyagi,
Dai Iwase,
Masashi Takaso
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s319537
Subject(s) - basic fibroblast growth factor , medicine , endocrinology , overweight , cd14 , body mass index , obesity , mast cell , immunology , growth factor , receptor
Obesity is associated with the risk of developing knee osteoarthritis (KOA). Furthermore, synovial basic fibroblast growth factor (bFGF) is linked to the severity of KOA. We previously demonstrated that bFGF and mast cell (MC) marker expression were elevated in the synovial tissues (ST) of KOA patients with obesity. However, it remains unclear whether MCs contribute to bFGF expression and regulation.