Open AccessAdvances in Biological Functions and Clinical Studies of FGF21
Author(s) -
Wei Jye Lin,
Tianlei Zhang,
Yiyang Zhou,
Jufeng Zheng,
Zhenlang Lin
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s317096
Subject(s) - fgf21 , computational biology , biology , computer science , genetics , fibroblast growth factor , receptor
Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.