Open AccessOsteoclasts May Affect Glucose Uptake-Related Insulin Resistance by Secreting Resistin
Author(s) -
Xiangqi Li,
Fei Sun,
Jing Lu,
Jichen Zhang,
Jingnan Wang,
Hongling Zhu,
Min Gu,
Junhua Ma
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s316964
Subject(s) - resistin , rankl , insulin resistance , medicine , endocrinology , osteoclast , insulin , glucose uptake , chemistry , bone resorption , adipokine , activator (genetics) , receptor
Bone may play a role in the modulation of insulin sensitivity. Insulin resistance can be caused by increased resistin. However, whether osteoclasts affect the insulin resistance via resistin remains unclear. In the present study, we show the expression of resistin in osteoclasts and the possible underlying role of resistin on glucose uptake-related insulin resistance in vitro.