Open AccessFOXA1 Suppresses SATB1 Transcription and Inactivates the Wnt/β-Catenin Pathway to Alleviate Diabetic Nephropathy in a Mouse Model
Author(s) -
Hong Zhu,
Jiarui Peng,
Wei Li
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s314709
Subject(s) - wnt signaling pathway , foxa1 , diabetic nephropathy , medicine , endocrinology , kidney , catenin , cancer research , apoptosis , downregulation and upregulation , transcription factor , chemistry , biology , microbiology and biotechnology , signal transduction , biochemistry , gene
Diabetic nephropathy (DN) represents the most common diabetic complication that may lead to end-stage renal disease. This work focused on the effect of FOXA1 on the DN development and the molecular mechanism.