Open AccessThe Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
Author(s) -
Peng Yu,
Li Huang,
Zhihan Wang,
Xiaoyu Meng,
Xuefeng Yu
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s312489
Subject(s) - insulin resistance , medicine , dyslipidemia , endocrinology , diabetes mellitus , body mass index , type 2 diabetes , uric acid , quartile , insulin , odds ratio , impaired fasting glucose , impaired glucose tolerance , confidence interval
Higher serum levels of uric acid (SUA) are associated with an increased risk of developing type 2 diabetes. Meanwhile, insulin resistance and beta-cell dysfunction are critical factors that mediate the progression from normal glucose tolerance to impaired fasting glucose (IFG) and type 2 diabetes. We aimed to investigate the association between SUA levels and insulin resistance and beta-cell dysfunction in individuals without diabetes, thus explicating the role of uric acid in the early stage of the natural history of type 2 diabetes.