Open Access[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles
Author(s) -
Meng-Yuan Shen,
Miao Wang,
Zhihua Liu,
Shurong Wang,
Yufeng Xie
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s306026
Subject(s) - apoptosis , umbilical vein , transfection , flow cytometry , downregulation and upregulation , microbiology and biotechnology , microrna , intracellular , microvesicles , endothelial stem cell , chemistry , human umbilical vein endothelial cell , biology , in vitro , biochemistry , gene
Humanin, a newly emerging endogenously expressed cytoprotective peptide, has been shown to have anti-apoptotic properties effects by protecting neuronal cells injury. Endothelial microparticles (EMPs) are considered as vital mediators in intercellular communication. EMPs may regulate various physiological and pathological processes by transferring mRNAs and microRNAs (miRNAs) to recipient cells.