Open AccessForsythoside A Alleviates High Glucose-Induced Oxidative Stress and Inflammation in Podocytes by Inactivating MAPK Signaling via MMP12 Inhibition
Author(s) -
Xiangchun Quan,
Huihui Liu,
Dongmei Ye,
Xinling Ding,
Xiulan Su
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s305092
Subject(s) - nox4 , oxidative stress , viability assay , chemistry , superoxide dismutase , malondialdehyde , mapk/erk pathway , apoptosis , p38 mitogen activated protein kinases , nadph oxidase , inflammation , microbiology and biotechnology , endocrinology , medicine , signal transduction , biology , biochemistry
Podocyte injury serves an important role during the progression of diabetic nephropathy (DN). The aim of this study was to investigate the effects of forsythoside A (FA) on high glucose (HG)-induced podocyte injury and to identify the possible mechanisms.