Open AccessmiR-140-5p Aggravates Insulin Resistance via Directly Targeting GYS1 and PPP1CC in Insulin-Resistant HepG2 Cells
Author(s) -
Xuemei Li,
Yonghong Yan,
Baoli Wang,
S. J. Zhao
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s304055
Subject(s) - insulin resistance , gene knockdown , insulin , downregulation and upregulation , glucose uptake , carbohydrate metabolism , microrna , glycogen , chemistry , biology , gene , medicine , microbiology and biotechnology , endocrinology , biochemistry
Much attention has been paid to the regulatory role of microRNA (miRNA) in insulin resistance. Nevertheless, how miR-140-5p regulates insulin resistance remains unclear. In this research, we aim to investigate the roles of miR-140-5p in insulin resistance.