Open AccessLncRNA PVT1 Regulates High Glucose-Induced Viability, Oxidative Stress, Fibrosis, and Inflammation in Diabetic Nephropathy via miR-325-3p/Snail1 Axis
Author(s) -
Bo Qin,
Xiaoli Cao
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s303151
Subject(s) - diabetic nephropathy , viability assay , inflammation , oxidative stress , downregulation and upregulation , fibrosis , in vivo , chemistry , pvt1 , western blot , in vitro , cancer research , diabetes mellitus , microbiology and biotechnology , endocrinology , medicine , biology , biochemistry , long non coding rna , gene
Diabetic nephropathy (DN), as a complication of diabetes, is a leading cause of mortality in diabetic patients. It has been reported that lncRNA PVT1 (PVT1) could accelerate the progression of DN by promoting ECM accumulation and increasing the expression of fibronectin 1 (FN1). However, the underlying mechanism of PVT1 on DN remains unknown.