Open AccessDPP-4 Inhibitors Have Different Effects on Endothelial Low-Grade Inflammation and on the M1-M2 Macrophage Polarization Under Hyperglycemic Conditions
Author(s) -
Valeria De Nigris,
Francesco Prattichizzo,
Hiroaki Iijima,
Antonio Ceriello
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s302621
Subject(s) - macrophage polarization , inflammation , sitagliptin , chemistry , population , lipopolysaccharide , endocrinology , enos , macrophage , pharmacology , medicine , metformin , biology , in vitro , biochemistry , insulin , nitric oxide , nitric oxide synthase , environmental health
We explored the anti-inflammatory role of the DPP-4 inhibitor teneligliptin, using sitagliptin as comparator, in different in vitro models of low-grade inflammation (LGI), evaluating the hyperglycemia-induced endothelial inflammation, the macrophage polarization, and the endothelium-macrophage interaction.