Open AccessSalusin-β Mediates High Glucose-Induced Inflammation and Apoptosis in Retinal Capillary Endothelial Cells via a ROS-Dependent Pathway in Diabetic Retinopathy
Author(s) -
Hao Wang,
Meng Zhang,
Hongli Zhou,
Lang Cao,
Jie Zhou,
Qinyun Chen,
Xuedong Zhang
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s301157
Subject(s) - diabetic retinopathy , apoptosis , inflammation , blot , medicine , retinal , endocrinology , downregulation and upregulation , diabetes mellitus , reactive oxygen species , flow cytometry , biology , immunology , ophthalmology , microbiology and biotechnology , biochemistry , gene
Diabetic retinopathy (DR) is characterized by retinal vascular endothelial cell death and vascular inflammation, which are microvascular complications of diabetes mellitus (DM). Salusin-β, a newly identified peptide, is closely associated with hypertension, atherosclerosis and diabetic cardiomyopathy. However, the exact role of salusin-β in high glucose (HG)-induced retinal capillary endothelial cell (REC) inflammation and apoptosis remains unclear.