Open AccessGene Expression Profiling of Apoptotic Proteins in Circulating Peripheral Blood Mononuclear Cells in Type II Diabetes Mellitus and Modulation by Metformin
Author(s) -
Mohammed Al Dubayee,
Ali Alshahrani,
Dana Aljada,
Mahmoud Zahra,
Ahmed Alotaibi,
Ibrahim Ababtain,
Malik Alnaim,
Ali M Alahmari,
Abdullah S. Al-Jarallah,
Muhammad Affan Elahi,
Hana Fakhoury
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s300048
Subject(s) - metformin , peripheral blood mononuclear cell , apoptosis , caspase 3 , downregulation and upregulation , insulin resistance , caspase , type 2 diabetes mellitus , endocrinology , caspase 2 , immunology , inflammation , medicine , diabetes mellitus , biology , programmed cell death , gene , biochemistry , in vitro
Insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is associated with cardiovascular complications such as atherosclerosis. On the other hand, the reduction of apoptosis in macrophages has been linked with accelerated atherosclerosis. Apoptosis is controlled by a different family of proteins including Bcl-2 and caspases.