Open AccessBone Autophagy: A Potential Way of Exercise-Mediated Meg3/P62/Runx2 Pathway to Regulate Bone Formation in T2DM Mice
Author(s) -
Xianghe Chen,
Yang Kang,
Xing Jin,
Zhaoxiang Meng,
Bo Liu,
Huilin Yu,
Pengcheng Lu,
Kui Wang,
Zhongjie Fan,
Ziang Tang,
Feng Zhang,
Chengye Liu
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s299744
Subject(s) - runx2 , autophagy , endocrinology , pi3k/akt/mtor pathway , medicine , chemistry , osteoblast , western blot , protein kinase b , microbiology and biotechnology , biology , signal transduction , biochemistry , apoptosis , gene , in vitro
Meg3 has been shown to attenuate T2DM bone autophagy by activating p62 to inhibit bone formation. However, whether exercise can reverse this process to promote T2DM bone formation and its mechanism remains unknown.