Open AccessEpidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation
Author(s) -
Yunyan Sun,
Ming Deng,
Xiao Xue Ke,
Xiangyang Lei,
Hao Ju,
Zhiming Liu,
Xiaosu Bai
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s299562
Subject(s) - pi3k/akt/mtor pathway , podocyte , biology , dna methylation , cell growth , protein kinase b , autophagy , microbiology and biotechnology , nephrin , epidermal growth factor , cancer research , signal transduction , apoptosis , gene expression , endocrinology , biochemistry , kidney , gene , receptor , proteinuria
Diabetic nephropathy (DN) is a serious health problem worldwide. Epidermal growth factor (EGF) has suggested as a potential biomarker for the progression of chronic kidney disease. In this study, we examined the effects of EGF on the high glucose (HG)-induced podocyte injury and explored the underlying molecular mechanisms.