Open AccessEmodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway
Author(s) -
Hong Liu,
Quan Wang,
Ge Shi,
Wenqiang Yang,
Yanmin Zhang,
Weidong Chen,
Shouhong Wan,
Fei Xiong,
Zengsi Wang
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s299375
Subject(s) - podocyte , autophagy , pi3k/akt/mtor pathway , nephrin , diabetic nephropathy , ampk , emodin , kidney , medicine , endocrinology , apoptosis , chemistry , pharmacology , microbiology and biotechnology , biology , protein kinase a , kinase , biochemistry , proteinuria
The activation of autophagy has potential protective effect on diabetic nephropathy (DN) podocyte injury, and the AMPK/mTOR signaling pathway is an important regulatory pathway of autophagy. Emodin has been reported to effectively delay DN progression; however, the therapeutic mechanisms involved in vivo remain ambiguous. The present study aimed to elucidate the mechanism of emodin in improving renal tissue and podocyte injury in DN by regulating the AMPK/mTOR-autophagy signaling pathway.