Open AccessSilencing of miR-20b-5p Exerts Inhibitory Effect on Diabetic Retinopathy via Inactivation of THBS1 Gene Induced VEGF/Akt/PI3K Pathway
Author(s) -
Yang Ma,
ChunYing Dong,
XiHui Chen,
Ruixi Zhu,
Jie Wang
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s299143
Subject(s) - gene silencing , protein kinase b , pi3k/akt/mtor pathway , inhibitory postsynaptic potential , vegf receptors , diabetic retinopathy , diabetes mellitus , gene , chemistry , medicine , cancer research , microbiology and biotechnology , signal transduction , biology , endocrinology , biochemistry
Diabetic retinopathy (DR) is a damaging complication of the eye. Studies investigating molecular mechanisms of DR are lacking, leading to poor clinical outcomes. miR-20b-5p is up-regulated in DR. The present study aimed to confirm the involvement of miR-20b-5p in DR and the mechanism involved.