Open AccessAtorvastatin Regulates MALAT1/miR-200c/NRF2 Activity to Protect Against Podocyte Pyroptosis Induced by High Glucose
Author(s) -
Yi Zuo,
Li Chen,
Xiaoyun He,
Zhen Ye,
Ling Li,
Zhanhong Liu,
ShiPing Zhou
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s298950
Subject(s) - pyroptosis , downregulation and upregulation , podocyte , oxidative stress , gene knockdown , chemistry , atorvastatin , diabetic nephropathy , flow cytometry , kidney , apoptosis , pharmacology , endocrinology , microbiology and biotechnology , medicine , biology , biochemistry , programmed cell death , proteinuria , gene
Diabetic nephropathy (DN) is one of the main complications of diabetes mellitus (DM), which leads to the long-term loss of kidney functions. Long noncoding RNAs (LncRNAs) can alleviate DN by interacting with microRNAs (miRNAs). In this work, we aimed to explore the effects of the MALAT1/miR-200c/NRF2 regulatory axis on the pyroptosis and oxidative stress (Oxidative stress, OS) of renal podocytes in high glucose (HG) environment and whether the lipid-lowering drug atorvastatin (AT) can relieve renal OS through this approach.