Open AccessRoux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus
Author(s) -
Chunjie Su,
Qian Cheng,
Liyun Wang
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s298897
Subject(s) - insulin resistance , blot , medicine , endocrinology , downregulation and upregulation , carbohydrate metabolism , insulin , diabetes mellitus , immunohistochemistry , hepatocyte , biology , irs1 , insulin receptor , in vitro , biochemistry , gene
Roux-en-Y gastric bypass (RYGB) is the most effective treatment for type 2 diabetes mellitus (T2DM). Previous studies have reported that silent information regulator 1 (Sirt1) closely relates to many pathological processes of glucose metabolism and insulin resistance (IR). However, it is unclear whether Sirt1 is involved in the hepatic glucose metabolism of T2DM after RYGB.