Open AccessGIP Receptor Antagonist, SKL-14959 Indicated Alteration of the Lipids Metabolism to Catabolism by the Inhibition of Plasma LPL Activity, Resulting in the Suppression of Weight Gain on Diets-Induced Obesity Mice
Author(s) -
Takashi Nakamura,
Hitomi Tanimoto,
Masayuki Okamoto,
Miki Takeuchi,
Yoshiharu Tsubamoto,
Hitoshi Noda
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s297353
Subject(s) - medicine , endocrinology , lipoprotein lipase , adipose tissue , catabolism , chemistry , lipid metabolism , hepatic lipase , weight gain , white adipose tissue , insulin , metabolism , biology , body weight
Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in the regulation of lipid metabolism via lipoprotein lipase (LPL). GIP receptor antagonist, SKL-14959, suppressed the weight gain in the diet-induced obesity model. However, the mechanism is not unclear. Therefore, we aimed to give insight into the reason.