Open AccessThe β3 Adrenergic Receptor Agonist CL316243 Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats by Activating AMPK/PGC-1α Signaling in Skeletal Muscle
Author(s) -
Lihua Ding,
Ya Wen Cheng,
Luyao Xu,
Lequan Zhou,
Li Guan,
Haimei Liu,
Yaxing Zhang,
Runmei Li,
Jin-Wen Xu
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s297351
Subject(s) - medicine , ampk , endocrinology , skeletal muscle , amp activated protein kinase , protein kinase a , carnitine , agonist , peroxisome proliferator activated receptor , soleus muscle , chemistry , phosphorylation , western blot , receptor , biology , biochemistry , gene
Skeletal muscle has a major influence on whole-body metabolic homeostasis. In the present study, we aimed to determine the metabolic effects of the β3 adrenergic receptor agonist CL316243 (CL) in the skeletal muscle of high-fat diet-fed rats.