Open AccessEffects of Curcumin on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells Through the TLR4-NF-κB Signaling Pathway
Author(s) -
Xinhui Liu,
Xiuli Zhang,
Xiaoyi Cai,
Jiqiu Dong,
Yinmao Chi,
Zhihong Chen,
Harvest F. Gu
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s296990
Subject(s) - curcumin , epithelial–mesenchymal transition , fibrosis , tlr4 , cancer research , signal transduction , nf κb , mesenchymal stem cell , chemistry , microbiology and biotechnology , downregulation and upregulation , biology , pathology , medicine , biochemistry , gene
Diabetic kidney disease (DKD) is a microvascular complication in diabetes mellitus, while tubuloepithelial to mesenchymal transition (EMT) of mature tubular epithelial cells is a key point in the early development and progression of renal interstitial fibrosis. The present study aimed to investigate the protective effects of Curcumin on EMT and fibrosis in cultured normal rat kidney tubular epithelial cell line (NRK-52E).