Open AccessInsulin, but Not Metformin, Supports Wound Healing Process in Rats with Streptozotocin-Induced Diabetes
Author(s) -
Mateusz Mieczkowski,
Beata Mrozikiewicz-Rakowska,
Tomasz Siwko,
Magdalena BujalskaZadrożny,
Anna de Cordé-Skurska,
Renata Wolińska,
Emilia Gąsińska,
Tomasz Grzela,
Piotr Foltyński,
Michał Kowara,
Zofia Mieczkowska,
Leszek Czupryniak
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s296287
Subject(s) - metformin , medicine , streptozotocin , insulin , diabetes mellitus , wound healing , glycemic , h&e stain , saline , endocrinology , immunohistochemistry , surgery
Optimal glycemic control is crucial for proper wound healing in patients with diabetes. However, it is not clear whether other antidiabetic drugs support wound healing in mechanisms different from the normalization of blood glucose control. We assessed the effect of insulin and metformin administration on the wound healing process in rats with streptozotocin-induced diabetes.