Open AccessPARP-1 and SIRT-1 are Interacted in Diabetic Nephropathy by Activating AMPK/PGC-1α Signaling Pathway
Author(s) -
Hengmei Zhu,
Zhi Fang,
Chen Jie-hui,
Yun Yang,
Jiacheng Gan,
Liang Luo,
Xiaojiang Zhan
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s291314
Subject(s) - ampk , poly adp ribose polymerase , endocrinology , diabetic nephropathy , western blot , medicine , blot , parp inhibitor , sirtuin 1 , downregulation and upregulation , chemistry , biology , microbiology and biotechnology , diabetes mellitus , protein kinase a , kinase , biochemistry , polymerase , enzyme , gene
Diabetic nephropathy (DN) is a metabolic disorder characterized by the accumulation of extracellular matrix (ECM). This study aims to investigate whether exists an interplay between poly (ADP-ribose) polymerase 1 (PARP-1) and sirtuin 1 (SIRT-1) in DN via AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) signaling pathway.