Open Access<p>Autologous Fat Grafting Promotes Macrophage Infiltration to Increase Secretion of Growth Factors and Revascularization, Thereby Treating Diabetic Rat Skin Defect</p>
Author(s) -
Ye Wang,
Hao Zhang,
Min Zhou,
Xinzeyu Yi,
Ping Duan,
Aixi Yu,
Baiwen Qi
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s286787
Subject(s) - extracellular matrix , adipose tissue , wound healing , revascularization , infiltration (hvac) , secretion , medicine , macrophage , immunology , biology , microbiology and biotechnology , materials science , biochemistry , in vitro , myocardial infarction , composite material
Diabetic skin defect is difficult to manage in surgical clinics, and there is still lack of effective treatments for diabetic skin defects. Currently, autologous fat grafting (AFG) is promising in the field of reconstructive surgery, while macrophage infiltration in autologous adipose tissue is considered vital for tissue regeneration. But AFG is rarely applied to the treatment of diabetic skin defects, and whether macrophage infiltration assists AFG to promote wound healing is still unknown.