Open Access<p><em>p53</em> Mediates GnRH Secretion via <em>Lin28/let-7</em> System in GT1-7 Cells</p>
Author(s) -
Ting Chen,
Haiying Wu,
Xiuli Chen,
Rongrong Xie,
Fengyun Wang,
Haixiang Sun,
Linqi Chen
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s279901
Subject(s) - secretion , downregulation and upregulation , kisspeptin , lin28 , endocrinology , medicine , biology , cell culture , stimulation , chemistry , cancer research , microbiology and biotechnology , hypothalamus , gene , transcription factor , biochemistry , sox2 , genetics
The well-known tumor suppressor transcriptional factor p53 has been proposed to be one of the central hubs of a functionally related and hierarchically arranged gene network coordinating pubertal timing. Our previous studies revealed that p53 is involved in the metabolic control of puberty. The current study aimed to investigate the underlying signaling pathway, through which p53 mediated the metabolic control of puberty.