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The well-known tumor suppressor transcriptional factor p53 has been proposed to be one of the central hubs of a functionally related and hierarchically arranged gene network coordinating pubertal timing. Our previous studies revealed tha p53 is involved in the metabolic control of puberty. The current study aimed to investigate the underlying signaling pathway, through which p53 mediated the metabolic control of puberty.

<p><em>p53</em> Mediates GnRH Secretion via <em>Lin28/let-7</em> System in GT1-7 Cells</p>