Open Access<p>Adiponectin Protects Obese Rats from Aggravated Acute Lung Injury via Suppression of Endoplasmic Reticulum Stress</p>
Author(s) -
Ke Wei,
Jie Luo,
Jian Cao,
Lihua Peng,
Li Ren,
Fan Zhang
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s278684
Subject(s) - endocrinology , unfolded protein response , adiponectin , medicine , bronchoalveolar lavage , endoplasmic reticulum , chop , inflammation , apoptosis , tumor necrosis factor alpha , lipopolysaccharide , lung , downregulation and upregulation , chemistry , obesity , insulin resistance , biochemistry , lymphoma , gene
Endoplasmic reticulum (ER) stress seems to mediate the obesity-induced susceptibility to acute lung injury (ALI). The present study was designed to evaluate the role of ER stress in adiponectin (APN)-induced lung protection in an obese rat model treated with lipopolysaccharide (LPS).