Open Access<p>Mogroside IIIE Alleviates High Glucose-Induced Inflammation, Oxidative Stress and Apoptosis of Podocytes by the Activation of AMPK/SIRT1 Signaling Pathway</p>
Author(s) -
Wei Xue,
Juhua Mao,
Qingjie Chen,
Weide Ling,
Yuemei Sun
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s276184
Subject(s) - ampk , apoptosis , oxidative stress , chemistry , viability assay , inflammation , signal transduction , microbiology and biotechnology , biochemistry , biology , immunology , protein kinase a , phosphorylation
Diabetic nephropathy (DN) is the leading cause of impaired renal function. The purpose of this study was to investigate the effects of Mogroside IIIE (MG IIIE), a cucurbitane-type compound isolated from Siraitia grosvenorii , in high glucose (HG)-induced podocytes and the possible mechanisms.