Open Access<p>High-Intensity Interval Training Attenuates Ketogenic Diet-Induced Liver Fibrosis in Type 2 Diabetic Mice by Ameliorating TGF-β1/Smad Signaling</p>
Author(s) -
Qiang Zhang,
Fei Shen,
Wenqing Shen,
Jie Xia,
Jing Wang,
Yu Zhao,
Zhe Zhang,
Yi Sun,
Min Qian,
Shuzhe Ding
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s275660
Subject(s) - endocrinology , medicine , interval training , high intensity interval training , smad , type 2 diabetes , insulin resistance , ketogenic diet , fibrosis , sed , insulin , diabetes mellitus , transforming growth factor , psychiatry , epilepsy
Ketogenic diet (KD) and high-intensity interval training (HIIT) have preclinical benefits for type 2 diabetes (Db). However, the health risks of long-term KD use in diabetes should be ascertained and prevented. We hypothesized that KD-induced liver fibrosis in type 2 diabetic mice could be ameliorated by HIIT.