Open Access<p>ZG02 Improved Hepatic Glucose Metabolism and Insulin Sensitivity via Activation of AMPK/Sirt1 Signaling Pathways in a High-fat Diet/Streptozotocin-induced Type 2 Diabetes Model</p>
Author(s) -
Yi Zhang,
Bo Zhou,
Min Wen,
Mi Hu,
Jin-Gang Peng,
Ying Wang,
Lei Fan,
Lei Tang
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s275145
Subject(s) - medicine , endocrinology , ampk , streptozotocin , type 2 diabetes , diabetes mellitus , insulin , amp activated protein kinase , insulin resistance , metabolism , phosphorylation , chemistry , protein kinase a , biochemistry
The aim of the present study was to investigate the hypoglycemic activity and potential mechanism of tetrahydrocarbazole derivatives ZG02 in high-fat diet/streptozotocin-induced type 2 diabetes model.